In aquaculture, trace minerals such as copper, iron, zinc, magnesium and manganese are essential for growth, immunity, and metabolic functions. However, conventional inorganic mineral supplements, often added as sulfates or oxides, suffer from critical limitations that affect their effectiveness. Studies reveal that inorganic minerals exhibit low absorption rates (10–30% on average) in aquatic species due to their susceptibility to antagonistic interactions in water and the digestive tract. For instance, copper sulfate may bind with phytates or other organic compounds in feed, forming insoluble complexes that pass unabsorbed through the intestine. Similarly, zinc oxide dissociates rapidly in water, losing bioavailability before reaching target tissues.

This poor utilization forces farmers to overdose minerals to meet nutritional requirements but increase their costs and cause unintended consequences. Excess inorganic minerals accumulate in pond water, inhibiting beneficial bacteria, promoting algal blooms, and contaminating ecosystems. Even worse, mineral unbalanced in aquatic animals can suppress immune responses, delay molting in shrimp, and growth slowing, these issues that directly reduce farmer’s final profitability.

These challenges make farmers needs urgently for a smarter, science-driven approach to mineral supplementation. BIO-AMIPLUS, a cutting-edge liquid supplement developed by Bivigro Animal Health Limited, addresses these challenges by combining the benefits of bioavailable trace minerals and essential amino acids in a single, highly efficient formulation. Designed specifically for aquatic species, this innovative product adopted advanced chelation technology to deliver nutrients in their most absorbable forms, maximizing their utilization by fish and shrimp while minimizing waste.

At the core of BIO-AMIPLUS contains a unique blend of three limiting amino acids, lysine, methionine, and threonine, which chelated with essential trace minerals including copper, iron, manganese, and zinc. Limiting amino acids are those most likely to be deficient in standard aquaculture feeds. By binding these amino acids to minerals through chelation, BIO-AMIPLUS ensures both components are protected from antagonistic interactions in the gut or water environment. This process enhances stability and allows simultaneous absorption of amino acids and minerals in the intestine, a significant improvement over conventional inorganic mineral supplements, which often exhibit poor bioavailability and compete for absorption pathways.

The chelated structure of BIO-AMIPLUS particularly effective for aquatic animals with short digestive tracts. For instance, studies show that chelated minerals in BIO-AMIPLUS are absorbed up to 40–60% more efficiently than inorganic counterparts, directly translating to improved enzyme activity, antioxidant capacity, and osmoregulation in fish and shrimp.

BIO-AMIPLUS is designed for both freshwater and marine aquaculture operations. When added to feed or water, it gives two critical nutritional benefits:

(1) Enhanced Growth Performance: Lysine, methionine, and threonine are critical for muscle development, molt cycles (in shrimp), and immune function. Supplementing these amino acids ensures balanced protein synthesis, leading to faster growth rates and improved feed conversion ratios (FCR). Trials in tilapia farms demonstrated a 15–20% increase in weight gain over 8 weeks when BIO-AMIPLUS was incorporated into daily feed.

(2) Disease Resistance and Anti-Stress: The chelated minerals in BIO-AMIPLUS play vital roles in strengthening immunity. Zinc and copper, for example, enhance epithelial barrier function and lymphocyte activity, reducing susceptibility to infections like vibriosis. During seasonal temperature fluctuations or salinity changes, manganese and iron support antioxidant enzymes (e.g., superoxide dismutase), mitigating oxidative stress and mortality risks.

(3) Environmental Sustainability: By improving nutrient absorption efficiency, BIO-AMIPLUS reduces mineral excretion into water bodies, lowering the risk of eutrophication and algal blooms. This aligns with global trends toward eco-friendly aquaculture practices.

To illustrate BIO-AMIPLUS’s mode of action, the diagram highlights how chelated minerals and amino acids are transported across the intestinal lining without dissociation, ensuring direct uptake into the bloodstream, further demonstrates the superior absorption rates of BIO-AMIPLUS versus traditional supplements, based on trial data from shrimp hatcheries.

BIO-AMIPLUS offering a scientifically solution to enhance productivity, health, and sustainability in aquaculture. Its dual action formula bridging amino acid gaps and delivering bioavailable minerals, makes it indispensable for farmers aiming to optimize yields while reducing environmental impact.